Mobile pupillometry for early neurological detection.
The Problem
Parkinson's disease begins degenerating the Locus Coeruleus — the brain's primary norepinephrine source — 5 to 7 years before motor symptoms appear. By the time of clinical diagnosis, significant neurological damage has already occurred. Early detection requires a window into LC–NE system dynamics. The pupil is that window.
The Approach
irispectra is developing a smartphone-based pupillometry protocol that measures LC–NE system activity through pupillary dynamics. A 5-minute session. No clinical hardware. No specialist required. The same parameters measured in research-grade laboratory settings — delivered through a standard smartphone camera and a custom 940nm IR module.
The Protocol
Resting pupil diameter, tonic LC–NE activity, hippus
Task-evoked pupil dilation (TEPD), phasic LC response
Autonomic reactivity, recovery time, sensitization index
Constriction latency, velocity, dilation recovery
Target Conditions
Pupillary dynamics reflect the state of the LC–NE system — a common pathway implicated across multiple neurological and psychiatric conditions. The same 5-minute protocol generates condition-relevant signal profiles for research across:
PLR velocity, autonomic recovery
PLR latency, cholinergic markers
emotional inertia, recovery asymmetry
baseline elevation, variability index
phasic LC instability, attention lapse indicators
regulation gain, baseline drift
irispectra does not diagnose any condition. these represent active research directions.
Core Parameters
tonic arousal
cognitive load
brainstem conduction
parasympathetic capacity
autonomic regulation
signal reliability
Collaboration
irispectra is actively seeking academic and clinical collaborators for protocol validation, pilot studies, and joint publication. Target areas include Parkinson's disease, autonomic dysregulation, and mobile neurological biomarkers. If your research intersects with any of these domains, we would welcome a conversation.
contact usirispectra research is a non-clinical initiative. this platform does not provide medical diagnoses or treatment recommendations.